Thursday, June 9, 2016

CR 353: 33rd infusion and another head cold

Yesterday morning I awoke with my sinuses full of mucus. I think I've had more colds while on this Opdivo therapy than pre-therapy. And the colds seem to last longer and are nastier. The drug does mess around with my immune system, after all, so side effects are to be expected. The most common side effect still is an itching scalp. Sometimes the rash appears on other parts of my body, then dissipates. Given the choice between having metastatic tumors growing throughout my body, or an itchy scalp and occasional colds, I'll choose the latter. As the great troubadour Joe Walsh said, I can't complain but some times I still do.

Dr. Hahn listened to my chest and sent me upstairs for a chest x-ray. He wanted to rule out anything related to the Opdivo, so he ordered a chest x-ray. I asked if he had learned anything new at ASCO, and he said that the news was very encouraging regarding immunotherapy with checkpoint inhibitors. He told me that about 24% of patients were seeing partial or complete responses, with about 2/3 of that group having complete responses. Another 20% or so had stable disease. In other words, about half of all patients who had failed chemotherapy and had active metastatic growth had seen the progress of their cancers stopped or reversed due to immunotherapy. That's significantly higher than I had understood the data to show.

Dr. Hahn also said that the trial sponsor was interested in learning how patients who had complete responses fared under three scenarios: (1) completing the two-year trial, going off treatment, and seeing what happens; (2) suspending treatment earlier than two years and seeing what happens, with a guaranteed right to resume treatment if the cancer was to return; and (3) continuing treatment indefinitely. The default is option 1. Option 2 is available to me if I am interested (not really). Option 3 will be considered at the end of the two years, and is subject to the agreement of the drug maker. I appreciated his letting me know there were multiple options available to me, and it reinforced how proactive patients in clinical trials need to be.

We talked about what might happen after my trial ended and if my mets came back. Dr. Hahn said that there was no published data showing how mets BC patients fared in that event, but anecdotal evidence from other types of cancers suggested that a resumed round of immunotherapy might again slow or reverse the cancer growth in some patients. I likely could resume taking Opdivo, or as Dr. Hahn noted, since the FDA recently approved atezolizumab (aka MPDL3280A, trade name Tecentriq) for bladder cancer, I could take that without entering another clinical trial. Hopefully I won't need to cross that bridge, but it's good to know that new options are opening up.

With respect to the durability of my response, obviously the longer I go on the trial without relapse, the better. But for future prognostication, Dr. Hahn agreed that if I can hit the two year mark (March 2017) with no relapse, it bodes well for a more durable response. If I can hit the three year mark, then my odds of having a more durable response increase. In the absence of data showing longevity (I am part of the still-forming data set), I'm just taking it one day at a time.

Meanwhile, my youngest son is hitting his own milestones with senior-related events, his looming high school graduation, then imminent departure on his mission. I am grateful that my life has been spared so I can be with my family for these events. In the early days of my diagnosis, I doubted that I would live this long. It adds a certain sweetness to what might be an otherwise hectic time to appreciate how special each day really is. I am a happy man.

2 comments:

  1. I look forward to Ken's comments and report. He mentioned the ASCO meeting in Chicago. A nice report relative to Cancer and the progress being made (including immunotherapy) can be found at http://www.economist.com/news/science-and-technology/21700125-personalisation-cancer-treatments-leading-better-outcomes
    Which is from The Economist magazine June 11, 2016 page 78

    ReplyDelete
  2. I look forward to Ken's comments and report. He mentioned the ASCO meeting in Chicago. A nice report relative to Cancer and the progress being made (including immunotherapy) can be found at http://www.economist.com/news/science-and-technology/21700125-personalisation-cancer-treatments-leading-better-outcomes
    Which is from The Economist magazine June 11, 2016 page 78

    ReplyDelete

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